SulfonylureaPrescription only
Gliclazide
Tablet
Quick Summary
Gliclazide lowers blood sugar by increasing insulin release. It can cause low blood sugar.
Type 2 diabetes
Medical Uses
Type 2 diabetes: Often with metformin.
How it's taken
Take with breakfast or the first main meal. Don't skip meals.
Your doctor decides the right dose for you and how long to take it.
Your doctor decides the right dose for you. Follow their instructions and the label.
Common Side Effects
Low blood sugar
Shakiness and sweating.
Weight gain
Sometimes.
Stomach upset
Sometimes.
Interactions
Alcohol
Increases low sugar risk.
Beta blockers
Can hide low-sugar warning signs.
Critical Warnings
Low blood sugar
Black Box Warning: Shaking, sweating, confusion: take sugar straight away. Tell your doctor if it happens.
Kidney and liver problems
Dose adjustment needed.
Sources and further reading
Last updated 21 October 2026. For more detail, see these trusted health organisations.