GLP-1 receptor agonistPrescription only
Semaglutide
Weekly injection or daily tablet
Quick Summary
Semaglutide mimics a gut hormone that increases insulin, slows stomach emptying and reduces appetite.
Type 2 diabetes
Weight management
Medical Uses
Type 2 diabetes: Lowers blood sugar and heart risk.
Weight management: In people with obesity, as prescribed.
How it's taken
Injected once a week or taken as a daily tablet on an empty stomach, as prescribed. Doses are increased slowly.
Your doctor decides the right dose for you. Follow their instructions and the label.
Common Side Effects
Nausea
Common, especially at first.
Diarrhoea or constipation
Common.
Reduced appetite
Expected.
Interactions
Insulin or sulfonylureas
Low sugar risk.
Critical Warnings
Severe tummy pain
Black Box Warning: Could be pancreatitis or gallbladder problems.
Pregnancy
Stop before planning pregnancy.
Sources and further reading
Last updated 21 October 2026. For more detail, see these trusted health organisations.
- Semaglutide: drug information(opens in a new tab) · MedlinePlus, US National Library of Medicine
- Semaglutide: a medicine to manage type 2 diabetes or treat obesity(opens in a new tab) · NHS