SSRI antidepressantPrescription only

Sertraline

Tablet

Quick Summary

Sertraline is a selective serotonin reuptake inhibitor (SSRI). It increases the level of serotonin, a chemical messenger in the brain, which can improve mood and reduce anxiety.

Depression
Anxiety disorders
Obsessive-compulsive disorder (OCD)
Post-traumatic stress disorder (PTSD)

Medical Uses

Depression: Helps lift low mood and restore interest in daily life.
Anxiety disorders: Including panic disorder, social anxiety and generalised anxiety.
Obsessive-compulsive disorder (OCD): Reduces obsessive thoughts and compulsive behaviour.
Post-traumatic stress disorder (PTSD): Can help with symptoms after a traumatic event.

How it's taken

Sertraline is a tablet taken once a day, at the same time each day, with or without food. Your doctor decides the right dose for you and may change it over time.

It usually takes a few weeks to start working, and several weeks to feel the full effect. Don't stop suddenly; your doctor will help you reduce it slowly when it's time to stop.

Your doctor decides the right dose for you. Follow their instructions and the label.

Common Side Effects

Feeling sick and stomach upset

Common in the first weeks and usually settles.

Sleep changes

Trouble sleeping or feeling sleepy.

Headache and dizziness

Usually mild and improves over time.

Sexual side effects

Lower sex drive or difficulty with orgasm or erection.

Interactions

Other antidepressants and triptans

Taking them together can cause serotonin syndrome (see warnings).

Blood thinners and anti-inflammatory painkillers

Increase the risk of bleeding.

Alcohol

Can make you feel more drowsy and may worsen depression.

St John's wort

Shouldn't be taken with sertraline.

Critical Warnings

Thoughts of self-harm

Black Box Warning: Some people, especially under 25, may have more thoughts of suicide or self-harm when starting. Get help immediately: call 112 or a helpline such as Tele-MANAS (14416).

Serotonin syndrome

Black Box Warning: Rare but serious: confusion, agitation, fever, sweating, shaking and fast heartbeat. Get emergency help.

Don't stop suddenly

Stopping quickly can cause withdrawal symptoms such as dizziness, irritability and sleep problems.

Sources and further reading

Last updated 21 October 2026. For more detail, see these trusted health organisations.