Rheumatoid Factor and Anti-CCP Tests
Blood tests for antibodies linked with rheumatoid arthritis.
Quick Summary
To help diagnose rheumatoid arthritis.
Rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP) antibodies.
No preparation needed.
Overview
Anti-CCP is more specific for rheumatoid arthritis than RF.
Some people with RA test negative, and some healthy people test positive for RF.
What It Measures
RF
Antibody often present in RA.
Anti-CCP
More specific RA antibody.
How It's Performed
- 01
Preparation
Usually no special preparation. Tell the staff about medicines you take.
- 02
Blood sample
A small amount of blood is taken from a vein in your arm with a thin needle.
- 03
Afterwards
Press on the spot for a minute. A small bruise is common; you can go back to normal activities.
Reference Ranges
Note: Normal ranges vary by laboratory. Consult your report for the specific reference used.
| Parameter | Typical Range (Adult) | Units |
|---|---|---|
| Rheumatoid factor | Below 14 | IU/mL |
| Anti-CCP | Below 20 | U/mL |
Interpreting Results & Next Steps
Discuss with Doctor
Normal ranges differ between laboratories, ages and sexes; always use the range printed on your report and ask your doctor what your results mean.
If values are High:
Positive results support RA, especially both together.
Sources and further reading
Last updated 21 October 2026. For more detail, see these trusted health organisations.
- Rheumatoid Factor (RF) Test(opens in a new tab) · MedlinePlus, US National Library of Medicine
- CCP antibody test(opens in a new tab) · MedlinePlus, US National Library of Medicine