Serum Protein Electrophoresis
A blood test that separates proteins in the blood, used to look for multiple myeloma.
Quick Summary
To investigate unexplained anaemia, bone pain, high calcium or kidney problems.
Protein bands including any abnormal (monoclonal) protein.
No preparation.
Overview
An abnormal band (M-protein) may suggest myeloma or related conditions.
Further tests confirm the cause.
What It Measures
Protein bands
Albumin and globulins.
M-protein
Abnormal band.
How It's Performed
- 01
Preparation
Usually no special preparation unless your doctor advises.
- 02
Blood sample
A small amount of blood is taken from a vein in your arm.
- 03
Afterwards
Press on the spot; a small bruise is common.
Interpreting Results & Next Steps
Discuss with Doctor
Normal ranges differ between laboratories; use the range on your report. Your doctor will explain what your result means and what happens next.
If values are High:
A monoclonal band needs specialist follow-up.
Sources and further reading
Last updated 21 October 2026. For more detail, see these trusted health organisations.
- Protein Electrophoresis by Immunofixation Blood Test(opens in a new tab) · MedlinePlus, US National Library of Medicine