Infectious Disease• Updated 21 October 2026

Syphilis Test (VDRL/RPR, TPHA)

Blood tests for syphilis, routinely done in pregnancy.

Results: Usually within a day Specimen: Blood

Quick Summary

Primary Purpose

To diagnose syphilis and screen in pregnancy.

What It Measures

Non-treponemal tests (VDRL, RPR) and treponemal tests (TPHA).

Preparation

No preparation needed.

Overview

Two types of tests are used together to confirm infection.

VDRL titres are used to check treatment response.

What It Measures

VDRL/RPR

Screening and monitoring.

TPHA

Confirmation.

How It's Performed

  1. 01

    Preparation

    Usually no special preparation. Tell the staff about medicines you take.

  2. 02

    Blood sample

    A small amount of blood is taken from a vein in your arm with a thin needle.

  3. 03

    Afterwards

    Press on the spot for a minute. A small bruise is common; you can go back to normal activities.

Interpreting Results & Next Steps

Discuss with Doctor

False positives can occur in pregnancy and some illnesses. Normal ranges differ between laboratories, ages and sexes; always use the range printed on your report and ask your doctor what your results mean.

If values are High:

A positive result needs confirmation and treatment.

Sources and further reading

Last updated 21 October 2026. For more detail, see these trusted health organisations.

Related Topics

Syphilis