RetinoidPrescription only
Isotretinoin
Capsule
Quick Summary
Isotretinoin shrinks oil glands and can clear acne for the long term.
Severe acne
Medical Uses
Severe acne: Including scarring or cystic acne.
How it's taken
Take with food under dermatologist supervision, with regular check-ups.
Your doctor decides the right dose for you and how long to take it.
Your doctor decides the right dose for you. Follow their instructions and the label.
Common Side Effects
Dry lips and skin
Very common.
Dry eyes
Common.
Joint and muscle aches
Sometimes.
Interactions
Tetracycline antibiotics
Risk of raised brain pressure.
Vitamin A supplements
Avoid.
Critical Warnings
Pregnancy
Black Box Warning: Causes severe birth defects; effective contraception is essential.
Thoughts of self-harm
Black Box Warning: Get help immediately: call 112 or Tele-MANAS (14416).
Blood tests
Liver and cholesterol checks.
Sources and further reading
Last updated 21 October 2026. For more detail, see these trusted health organisations.
- Isotretinoin: drug information(opens in a new tab) · MedlinePlus, US National Library of Medicine
- Isotretinoin: a medicine for severe acne(opens in a new tab) · NHS