Heart failure medicinePrescription only
Sacubitril-Valsartan
Tablet
Quick Summary
It blocks angiotensin and boosts natural substances that relax blood vessels and remove salt.
Heart failure
Medical Uses
Heart failure: With reduced pumping function.
How it's taken
Taken twice daily. Don't take with an ACE inhibitor; a gap is needed when switching.
Your doctor decides the right dose for you and how long to take it.
Your doctor decides the right dose for you. Follow their instructions and the label.
Common Side Effects
Dizziness
Low blood pressure.
Raised potassium
Blood tests.
Cough
Sometimes.
Interactions
ACE inhibitors
Must not be combined.
Potassium supplements
High potassium.
Critical Warnings
Not in pregnancy
Black Box Warning: Can harm an unborn baby.
Facial swelling
Black Box Warning: Angioedema: emergency.
Sources and further reading
Last updated 21 October 2026. For more detail, see these trusted health organisations.
- Valsartan and Sacubitril: drug information(opens in a new tab) · MedlinePlus, US National Library of Medicine