SNRIPrescription only

Duloxetine

Capsule

Quick Summary

Duloxetine increases serotonin and noradrenaline, improving mood and reducing pain signals.

Depression and anxiety
Diabetic nerve pain
Fibromyalgia

Medical Uses

Depression and anxiety: Daily treatment.
Diabetic nerve pain: Pain relief.
Fibromyalgia: Some people.

How it's taken

Swallow whole once or twice daily.

Your doctor decides the right dose for you and how long to take it.

Your doctor decides the right dose for you. Follow their instructions and the label.

Common Side Effects

Nausea

Common at first.

Dry mouth

Sometimes.

Sleep changes

Sometimes.

Interactions

Other antidepressants, tramadol and triptans

Risk of serotonin syndrome.

Alcohol

Liver risk.

Critical Warnings

Thoughts of self-harm

Black Box Warning: Get help immediately: call 112 or Tele-MANAS (14416).

Don't stop suddenly

Your doctor will help you reduce it slowly.

Liver disease

Not suitable for heavy drinkers or liver disease.

Sources and further reading

Last updated 21 October 2026. For more detail, see these trusted health organisations.

Related Topics

Peripheral NeuropathyDepression